3,5-DIFLUOROBENZAMIDOXIME synthesis

Yield:-

Reaction Conditions:

with hydroxylamine hydrochloride;potassium carbonate in methanol; for 12 h;Heating / reflux;

Steps:

12 3,5-Difluoro-N-hydroxy-benzamidine

100 mg (0.72 mmol, 1.00 eq) of 3,5-difluorobenzonitrile is dissolved in 4.00 mL of methanol and 149 mg (1.08 mmol, 1.50 eq) of potassium carbonate followed by 99.9 mg (1.44 mmol, 2.00 eq) of hydroxylamine hydrochloride are added. The reaction mixture is refluxed for 12 h, filtered and the solvent is evaporated. The crude product is purified by flash chromatography (silica gel, eluent: c-hexane:ethyl acetate = 3:2) to yield the title compound.

References:

EP1604989,2005,A1 Location in patent:Page/Page column 36-37