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3,5-DiMethoxypicolinonitrile synthesis

1synthesis methods
298709-29-2 Synthesis
2-Cyano-3,5-difluoropyridine

298709-29-2
211 suppliers
$11.00/1g

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Yield: 85%

Reaction Conditions:

in methanol at 100; for 12 h;

References:

Ernst, Justin T.;Thompson, Peggy A.;Nilewski, Christian;Sprengeler, Paul A.;Sperry, Samuel;Packard, Garrick;Michels, Theodore;Xiang, Alan;Tran, Chinh;Wegerski, Christopher J.;Eam, Boreth;Young, Nathan P.;Fish, Sarah;Chen, Joan;Howard, Haleigh;Staunton, Jocelyn;Molter, Jolene;Clarine, Jeff;Nevarez, Andres;Chiang, Gary G.;Appleman, Jim R.;Webster, Kevin R.;Reich, Siegfried H. [Journal of Medicinal Chemistry,2020,vol. 63,# 11,p. 5879 - 5955] Location in patent:supporting information