3,5-DIMETHYL-4-FLUORO-PHENYLBORONIC ACID synthesis
- Product Name:3,5-DIMETHYL-4-FLUORO-PHENYLBORONIC ACID
- CAS Number:342636-66-2
- Molecular formula:C8H10BFO2
- Molecular Weight:167.97
7397-43-5
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$63.89/5g
7732-18-5
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$13.50/100ML
99725-44-7
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342636-66-2
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Yield:342636-66-2 98%
Reaction Conditions:
Stage #1: 3,5-dimethyl-4-fluoro-1-bromobenzenewith n-butyllithium in tetrahydrofuran;hexane at -78; for 1 h;Inert atmosphere;
Stage #2: tri-(tert-butyl)borate in tetrahydrofuran;hexane at -78 - 20;Inert atmosphere;
Stage #3: waterwith hydrogenchloride in tetrahydrofuran;hexane at 20;Inert atmosphere;
References:
Cui, Lin-Song;Nomura, Hiroko;Geng, Yan;Kim, Jong U.k.;Nakanotani, Hajime;Adachi, Chihaya [Angewandte Chemie - International Edition,2017,vol. 56,# 6,p. 1571 - 1575][Angew. Chem.,2017,vol. 129,# 6,p. 1593 - 1597] Location in patent:supporting information