![](/CAS/GIF/16034-49-4.gif)
(3,5-DIMETHYL-PYRAZOL-1-YL)-ACETIC ACID synthesis
- Product Name:(3,5-DIMETHYL-PYRAZOL-1-YL)-ACETIC ACID
- CAS Number:16034-49-4
- Molecular formula:C7H10N2O2
- Molecular Weight:154.17
![methyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate](/CAS/20180713/GIF/79559-08-3.gif)
79559-08-3
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![(3,5-DIMETHYL-PYRAZOL-1-YL)-ACETIC ACID](/CAS/GIF/16034-49-4.gif)
16034-49-4
90 suppliers
$31.00/200 μmol
Yield: 100%
Reaction Conditions:
with water;lithium hydroxide in tetrahydrofuran at 0 - 20; for 2.5 h;
Steps:
17.2 Step 2: 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetic acid
The ester from step 1 (226.3 mg, 1.3 mmol) was dissolved in THF (4 mL) and cooled to 0 °C, then 1 N aqueouslithium hydroxide (1.48 mL, 1.5 mmol) was added and the reaction was allowed to warm to room temperature. After 2.5h, 1 M HCl was used to quench the reaction and the solution was concentrated to afford the title compound in quantitativeyield.
References:
Deutsches Krebsforschungszentrum;MILLER, Aubry;SCHÜLER, Peter;DE VITA, Elena EP3305781, 2018, A1 Location in patent:Paragraph 0363; 0364
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1000210-73-0
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![(3,5-DIMETHYL-PYRAZOL-1-YL)-ACETIC ACID](/CAS/GIF/16034-49-4.gif)
16034-49-4
90 suppliers
$31.00/200 μmol
![ethyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate](/CAS/20150408/GIF/10199-60-7.gif)
10199-60-7
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![(3,5-DIMETHYL-PYRAZOL-1-YL)-ACETIC ACID](/CAS/GIF/16034-49-4.gif)
16034-49-4
90 suppliers
$31.00/200 μmol
![3,5-Dimethylpyrazole](/CAS/GIF/67-51-6.gif)
67-51-6
541 suppliers
$6.00/25g
![Chloroacetic acid](/CAS/GIF/79-11-8.gif)
79-11-8
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$24.00/25g
![(3,5-DIMETHYL-PYRAZOL-1-YL)-ACETIC ACID](/CAS/GIF/16034-49-4.gif)
16034-49-4
90 suppliers
$31.00/200 μmol
![3,5-Dimethylpyrazole](/CAS/GIF/67-51-6.gif)
67-51-6
541 suppliers
$6.00/25g
![(3,5-DIMETHYL-PYRAZOL-1-YL)-ACETIC ACID](/CAS/GIF/16034-49-4.gif)
16034-49-4
90 suppliers
$31.00/200 μmol