![](/CAS/GIF/2510-36-3.gif)
3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID synthesis
- Product Name:3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID
- CAS Number:2510-36-3
- Molecular formula:C6H7NO3
- Molecular Weight:141.12
![ETHYL 3,5-DIMETHYLISOXAZOLE-4-CARBOXYLATE](/CAS/GIF/17147-42-1.gif)
17147-42-1
87 suppliers
$18.00/1g
![3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/2510-36-3.gif)
2510-36-3
195 suppliers
$5.00/1g
Yield: 94%
Reaction Conditions:
with sodium hydroxide in tetrahydrofuran;methanol;water at 20; for 8 h;
Steps:
1.6. 3,5-dimethylisoxazole-4-carboxylic acid (13)
To a solution of ethyl 3,5-dimethyl-4-isoxazolecarboxylate (2.4 g, 14 mmol) in THF (8 mL) and MeOH (8 mL) was added 5N aqueous NaOH (8.5 mL). The reaction was stirred at room temperature for 8 h. The reaction mixture was removed under reduced pressure and acidified with 6 N aqueous HCl to pH=2. The precipitated product was filtered, washed with water, and dried to afford 9 (2.1 g, 94.0%) as a white solid. 1H NMR (300 MHz, CDCl3) δ 2.72 (s, 3H), 2.49 (s, 3H).
References:
Qiu, Rongmao;Luo, Guoshun;Li, Xinyu;Zheng, Fan;Li, Haolin;Zhang, Jin;You, Qidong;Xiang, Hua [Bioorganic and Medicinal Chemistry Letters,2018,vol. 28,# 17,p. 2879 - 2884] Location in patent:supporting information
![4-(CHLOROMETHYL)-3,5-DIMETHYLISOXAZOLE](/CAS/GIF/19788-37-5.gif)
19788-37-5
167 suppliers
$13.43/1gm:
![3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/2510-36-3.gif)
2510-36-3
195 suppliers
$5.00/1g
![3,5-Dimethylisoxazole](/CAS/GIF/300-87-8.gif)
300-87-8
242 suppliers
$6.00/5g
![3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/2510-36-3.gif)
2510-36-3
195 suppliers
$5.00/1g
![(3,5-DIMETHYL-4-ISOXAZOLYL)METHANOL](/CAS/GIF/19788-36-4.gif)
19788-36-4
92 suppliers
$22.00/100mg
![3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/2510-36-3.gif)
2510-36-3
195 suppliers
$5.00/1g
![3,4,5-trimethyloxazole](/CAS/GIF/10557-82-1.gif)
10557-82-1
7 suppliers
inquiry
![3,5-DIMETHYLISOXAZOLE-4-CARBOXYLIC ACID](/CAS/GIF/2510-36-3.gif)
2510-36-3
195 suppliers
$5.00/1g