3-(6-BroMopyridin-3-yl)propan-1-ol synthesis
- Product Name:3-(6-BroMopyridin-3-yl)propan-1-ol
- CAS Number:656827-76-8
- Molecular formula:C8H10BrNO
- Molecular Weight:216.08
918145-42-3
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656827-76-8
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Yield:656827-76-8 96%
Reaction Conditions:
with lithium borohydride in tetrahydrofuran at 40; for 3 h;
Steps:
3.a
Under argon, 560 mg (2.17 mmol) of 3-(6-bromopyridin-3-yl)propionic acid ethyl ester and 94.6 mg (4.34 mmol) of lithium borohydride were stirred in 40 ml of THF at 40 °C for 3 h. After cooling, the mixture was cautiously hydrolyzed with water, the precipitate was filtered off with suction, and the filtrate was concentrated and admixed with water and ethyl acetate. The organic phase was separated, washed with water and concentrated. Yield: 450 mg (96 %). MS: M+H+ = 216.1.
References:
EP1741709,2007,A1 Location in patent:Page/Page column 30
656827-74-6
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656827-76-8
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149806-06-4
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656827-76-8
31 suppliers
$198.44/1g