3,6-Dichloro-2-Methylquinoxaline synthesis

6synthesis methods

Product Name:3,6-Dichloro-2-Methylquinoxaline
CAS Number:76672-21-4
Molecular formula:C9H6Cl2N2
Molecular Weight:213.06

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Yield:76672-21-4 86%

Reaction Conditions:

with trichlorophosphate at 120; for 5 h;

Steps:

4.1.3 General procedure for 2-chloro-3-methyl substituted quinoxaline (2)

General procedure: Compound 1a (28.1mmol, 5.0g) was dissolved in POCl₃ (25mL) at 0°C, the resulting solution was allowed to reflux at 120°C for 5h. After completion of reaction, the reaction was quenched with cooled ammonia, which was further extracted with ethyl acetate (EtOAc, 2×15mL). The organic phase was separated and washed with brine, dried over anhydrous MgSO₄, filtered, and concentrated in vacuum to afford the crude product, which was purified by silica gel flas chromatography (PE: EA=10:1, v:v) to afford 5.0g of 2a as an off-white solid, yield 90%.

References:

Xia, Qiao-Hong;Hu, Wei;Li, Chen;Wu, Ji-Feng;Yang, Liang;Han, Xue-Mei;Shen, Yue-Mao;Li, Zhi-Yu;Li, Xun [European Journal of Medicinal Chemistry,2016,vol. 124,p. 311 - 325] Location in patent:supporting information

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