ChemicalBook CAS DataBase List 3,6-DICHLORO-4-TRIFLUOROMETHYL-PYRIDAZINE

3,6-DICHLORO-4-TRIFLUOROMETHYL-PYRIDAZINE synthesis

2synthesis methods

Product Name:3,6-DICHLORO-4-TRIFLUOROMETHYL-PYRIDAZINE
CAS Number:1057672-68-0
Molecular formula:C5HCl2F3N2
Molecular Weight:216.98

4-(trifluoroMethyl)-1,2-dihydropyridazine-3,6-dione

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3,6-DICHLORO-4-TRIFLUOROMETHYL-PYRIDAZINE

1057672-68-0
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Yield: 76%

Reaction Conditions:

with trichlorophosphate at 120; for 1.5 h;Microwave irradiation;

Steps:

3.3
Step 3: 3,6-Dichloro-4-(trifTuoromethyl)pyridazine (C4)A solution of intermediate C3 (1.0 eq) in phosphorus oxychloride (22.0 eq) was stirred for 90 min at 120⁰C under MW irradiation. After completion of the reaction, solvent was evaporated under reduced pressure and the crude material purified by flash column chromatography on silica gel using 2-10% Et₂θ/Petroleum ether, the desired C4 was obtained as a white solid (76% yield). ¹H-NMR (400 MHz, CDCl₃, 300K) δ 7.79 (IH, s).

References:

ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. WO2009/63244, 2009, A1 Location in patent:Page/Page column 79

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1057672-68-0
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$70.00/250mg

References