3,6-Dihydroxy-4,5-dimethylpyridazine synthesis
- Product Name:3,6-Dihydroxy-4,5-dimethylpyridazine
- CAS Number:5754-17-6
- Molecular formula:C6H8N2O2
- Molecular Weight:140.14
Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).
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5754-17-6
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Yield:5754-17-6 99%
Reaction Conditions:
with hydrazine hydro-chloride in water;Reflux;
Steps:
4,5-Dimethyl-1,2-dihydro-pyridazine-3,6-dione (compound 36)
Hydrazine hydrochloride (58 g, 552 mmol) is dissolved in hot water (300 mL) and dimethyl maleic anhydride (58 g, 460 mmol) is added in portions and the suspension stirred at reflux for 16 h. The suspension is cooled down to room temperature and the precipitate is filtered, washed with water and dried at 40° C. under vacuum to yield 4,5-dimethyl-1,2-dihydro-pyridazine-3,6-dione (36) (64 g, 99%).1H-NMR (400 MHz, DMSO-d6) δ=11 (br s, 2H), 2.01 (s, 6H).MS (m/z, MH+) meas. 141.1.
References:
US2010/41663,2010,A1 Location in patent:Page/Page column 41
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5754-17-6
102 suppliers
$16.00/250mg
766-39-2
242 suppliers
$10.00/5g
63751-07-5
0 suppliers
inquiry
5754-17-6
102 suppliers
$16.00/250mg