3,9-Dichloroacridine synthesis

Yield:-

Reaction Conditions:

with trichlorophosphate at 130; for 3 h;

Steps:

2.2. 6, 9-Dichloro-2-methoxyacridine (4a)

General procedure: The crude product of 3a (2.00 g) was dissolved in POCl₃ (25 mL) and heated at 130 oC for 3 h. The reaction mixture was cooled to room temperature and poured into a mixture of crushed ice (150 g), ammonia (150 mL) and chloroform (200 mL) under vigorous stirring. The mixture was separated and the organic phase was evaporated to afford yellow solid. The crude solid was filtered and puri?ed by ethyl acetate.

References:

Lang, Xuliang;Li, Lulu;Chen, Yuzong;Sun, Qinsheng;Wu, Qin;Liu, Feng;Tan, Chunyan;Liu, Hongxia;Gao, Chunmei;Jiang, Yuyang [Bioorganic and Medicinal Chemistry,2013,vol. 21,# 14,p. 4170 - 4177] Location in patent:supporting information