3'-Acetamido-2-bromoacetophenone synthesis

4synthesis methods

Product Name:3'-Acetamido-2-bromoacetophenone
CAS Number:30095-56-8
Molecular formula:C10H10BrNO2
Molecular Weight:256.1

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Yield:30095-56-8 62.9%

Reaction Conditions:

with copper(I) bromide in ethyl acetate at 80;

Steps:

33.b

B) 3-Acetylaminoacetophenone (25 g, 141 mmol)And copper bromide (38 g, 169 mmol)Were successively dissolved in ethyl acetate (300 mL)The mixture was stirred overnight at 80 ° C,The reaction solution was cooled to room temperature,Followed by 500 mL of water,500 mL of saturated sodium chloride solution,The ethyl acetate layer was separated,Dried over anhydrous sodium sulfate,The organic solvent was distilled off under reduced pressure,The residue was purified by flash silica gel column chromatography,Eluting with petroleum ether / ethyl acetate (V / V = 10: 1)To give the title compound 22g,As a white solid,Yield 62.9%.

References:

CN103833671,2016,B Location in patent:Paragraph 0129; 0130; 0131; 0133