![](/CAS/GIF/586-42-5.gif)
3-ACETYLBENZOIC ACID synthesis
- Product Name:3-ACETYLBENZOIC ACID
- CAS Number:586-42-5
- Molecular formula:C9H8O3
- Molecular Weight:164.16
![3-ACETYLBENZONITRILE](/CAS/GIF/6136-68-1.gif)
6136-68-1
277 suppliers
$6.00/1g
![3-ACETYLBENZOIC ACID](/CAS/GIF/586-42-5.gif)
586-42-5
192 suppliers
$10.00/1g
Yield: 92%
Reaction Conditions:
Stage #1:3-acethylbenzonitrile with sodium hydroxide;water in methanol at 90;
Stage #2: with hydrogenchloride in water; pH=3
Steps:
105 Example 105; 3-ACETYL-BENZOIC acid
6M Sodium hydroxide (25 mL) was added to 3-acetylbenzonitrile (850 mg, 5.82 mmol) in methanol (25 mL) and then heated at [90°C] overnight. After concentrating the reaction mixture, the aqueous layer was washed with dichloromethane (2x), then acidified [PH-3] with 12M HC1. The precipitate was extracted with ethyl acetate then washed with water and saturated brine, dried over anhydrous sodium sulfate filtered and concentrated to afford 3-ethylbenzoic acid as a colorless oil; 0.800g (92%). 1H NMR [(CDC13)] 8 [(PPM)] : 8.70 (s, 2H), 8.33 (d, 2H), 8. 24 (d, 2H), 7.64 (t, 1H), 2.70 (s, 3H).
References:
ASTRA ZENECA AB;NPS PHARMACEUTICALS, INC. WO2004/14881, 2004, A2 Location in patent:Page 138
![3'-Methylacetophenone](/CAS/GIF/585-74-0.gif)
585-74-0
180 suppliers
$10.00/5g
![3-ACETYLBENZOIC ACID](/CAS/GIF/586-42-5.gif)
586-42-5
192 suppliers
$10.00/1g
![3-ETHYNYL-BENZOIC ACID](/CAS/GIF/10601-99-7.gif)
10601-99-7
90 suppliers
$11.00/250mg
![3-ACETYLBENZOIC ACID](/CAS/GIF/586-42-5.gif)
586-42-5
192 suppliers
$10.00/1g
![Carbon dioxide](/CAS/GIF/124-38-9.gif)
124-38-9
121 suppliers
$175.00/23402
![Methanesulfonic acid, 1,1,1-trifluoro-, 3-acetylphenyl ester](/CAS/20210305/GIF/138313-22-1.gif)
138313-22-1
1 suppliers
inquiry
![3-ACETYLBENZOIC ACID](/CAS/GIF/586-42-5.gif)
586-42-5
192 suppliers
$10.00/1g
![1,3-DIACETYLBENZENE](/CAS/GIF/6781-42-6.gif)
6781-42-6
170 suppliers
$8.00/1g
![3-ACETYLBENZOIC ACID](/CAS/GIF/586-42-5.gif)
586-42-5
192 suppliers
$10.00/1g