3-Allyl-4H-pyran-4-one synthesis
- Product Name:3-Allyl-4H-pyran-4-one
- CAS Number:1393533-99-7
- Molecular formula:C8H8O2
- Molecular Weight:136.15
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Yield:1393533-99-7 65%
Reaction Conditions:
Stage #1: 4-pyronewith zinc chloride-2,2,6,6-tetramethylpiperidin-1-ide lithium chloride complex in tetrahydrofuran at 0; for 2 h;Inert atmosphere;
Stage #2: with CuCN*2LiCl2 in tetrahydrofuran at -40; for 0.5 h;Inert atmosphere;
Stage #3: allyl bromide in tetrahydrofuran at -40 - 25; for 1.08333 h;Inert atmosphere;regioselective reaction;
References:
Klier, Lydia;Bresser, Tomke;Nigst, Tobias A.;Karaghiosoff, Konstantin;Knochel, Paul [Journal of the American Chemical Society,2012,vol. 134,# 33,p. 13584 - 13587] Location in patent:supporting information; experimental part