3-amino-1,2-propanediol, (±) synthesis

8synthesis methods

Product Name:3-amino-1,2-propanediol, (±)
CAS Number:13552-31-3
Molecular formula:C3H9NO2
Molecular Weight:0

56-82-6 Synthesis

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Yield:13552-31-3 94.5%

Reaction Conditions:

with ammonia;active charcoal;palladium in water;

Steps:

3 EXAMPLE 3

EXAMPLE 3 The corresponding ketimine is obtained analogously to Example 1 from glyceraldehyde and ammonia in water. After 10% by weight, relative to the amount of glyceraldehyde, of a 10% palladium/active charcoal catalyst has been added, hydrogenation is carried out at 50° and a hydrogen pressure of 65 bar. The mixture is filtered and evaporated and the residue is distilled, giving 1-amino-2,3-propanediol in a yield of 94.5% of theory.

References:

US5023379,1991,A