ChemicalBook CAS DataBase List 3-AMino-1-Boc-4,4-difluoropyrrolidine

3-AMino-1-Boc-4,4-difluoropyrrolidine synthesis

4synthesis methods

Product Name:3-AMino-1-Boc-4,4-difluoropyrrolidine
CAS Number:1408074-83-8
Molecular formula:C9H16F2N2O2
Molecular Weight:222.23

1434141-81-7 Synthesis

1434141-81-7
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1408074-83-8
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: pyridine / dichloromethane / 1 h / -10 °C / Inert atmosphere
2: tetrabutylammoniun azide / N,N-dimethyl-formamide / 16.25 h / Cooling with ice; Inert atmosphere
3: palladium on carbon; hydrogen / ethanol / 16 h

References:

PFIZER INC.;Behenna, Douglas Carl;Cheng, Hengmiao;Cho-Schultz, Sujin;Johnson, JR., Theodore Otto;Kath, John Charles;Nagata, Asako;Nair, Sajiv Krishnan;Planken, Simon Paul US2015/141402, 2015, A1

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

1000210-73-0
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1408074-83-8
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1000210-73-0
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1408074-83-8
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tert-butyl 3-azido-4-hydroxypyrrolidine-1-carboxylate

203434-45-1
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1408074-83-8
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References