3-amino-2,2-dimethylpropan-1-ol:hydrochloride synthesis

Yield:856816-26-7 46%

Reaction Conditions:

with hydrogenchloride;water;acetic acid for 24 h;Heating / reflux;

Steps:

44 Production of 3-amino-2,2-dimethylpropan-1-ol hydrochloride

Reference Example 44 Production of 3-amino-2,2-dimethylpropan-1-ol hydrochloride A mixture of compound (1.395 g, 4.0 mmol) obtained in Reference Example 43, concentrated hydrochloric acid (10 ml), acetic acid (7 ml) and water (10 ml) was refluxed for 24 hours. The reaction liquid was concentrated and water was added. The precipitated phthalic acid was filtered off and filtrate was concentrated. The residue was recrystallized from ethyl acetate to give the title compound (257.2 mg, 46 %) as pale purple crystals. ¹H-NMR(CDCl₃+ CD₃OD) δ: 2.91 (2H, brs), 3.38 (6H, brs), 3.52 (2H, brs).

References:

EP1591446,2005,A1 Location in patent:Page/Page column 97