3-AMINO-2-BROMOQUINOLINE synthesis
- Product Name:3-AMINO-2-BROMOQUINOLINE
- CAS Number:17127-83-2
- Molecular formula:C9H7BrN2
- Molecular Weight:223.07
580-17-6
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Yield:17127-83-2 36%
Reaction Conditions:
Stage #1: 3-aminoquinolinewith n-butyllithium in diethyl ether at -78 - 20;
Stage #2: with trimethyltin(IV)chloride in diethyl ether at -78; for 24 h;
Stage #3: with bromine in diethyl ether at -78 - 20; for 2 h;Further stages.;
References:
Smith, Michael B.;Guo, Lisa;Okeyo, Sherrad;Stenzel, Jason;Yanella, James;LaChapelle, Eric [Organic Letters,2002,vol. 4,# 14,p. 2321 - 2323]