3-amino-2-methylpropan-1-ol synthesis
- Product Name:3-amino-2-methylpropan-1-ol
- CAS Number:15518-10-2
- Molecular formula:C4H11NO
- Molecular Weight:89.14
88512-06-5
25 suppliers
$45.00/10mg
15518-10-2
45 suppliers
$65.00/50mg
Yield: 86%
Reaction Conditions:
with lithium aluminium tetrahydride in tetrahydrofuran at 0; for 3 h;Inert atmosphere;Reflux;
Steps:
2 Synthesis of aminoalcohol (D2).
D1 (2.0 g, 13.0 mmol) was added portionwise to a suspension of LiAIH4 (1.4 g, 39.2 mmol) in THF (75 ml_) under nitrogen atmosphere at 0 °C. The reaction mixture was stirred for 30 minutes and then allowed to stir at room temperature for another 30 minutes. The reaction mixture was refluxed for 2 h, and then it was cooled to -10 °C and quenched carefully with ice cold water (1.4 ml_). 10% NaOH solution (2.8 ml_) and ice cold water (4.2 ml_) were added, and the mixture was stirred for 15 minutes. It was filtered, and the filtrate washed with EtOAc (3 x 100 ml_), dried over anhydrous Na2S04 and concentrated under vacuum to obtain D2 (1.2 g, 86%) as a pale yellow liquid. Rf: 0.2 (20% MeOH in DCM). 1H NMR (400 MHz, cf6-DMSO): δ 0.78 (d, J = 6.8 Hz, 3H), 1.46 - 1.54 (m, 1 H), 2.41 - 2.45 (m, 2H), 2.50 - 2.54 (m, 1 H), 3.22 - 3.34 (m, 4H).
References:
Location in patent:Page/Page column 142
22560-81-2
36 suppliers
$333.00/1g
15518-10-2
45 suppliers
$65.00/50mg
10569-72-9
143 suppliers
inquiry
15518-10-2
45 suppliers
$65.00/50mg
89333-65-3
0 suppliers
inquiry
15518-10-2
45 suppliers
$65.00/50mg