3-AMINO-3-(2,4-DIMETHOXY-PHENYL)-PROPIONIC ACID synthesis
- Product Name:3-AMINO-3-(2,4-DIMETHOXY-PHENYL)-PROPIONIC ACID
- CAS Number:34841-02-6
- Molecular formula:C11H15NO4
- Molecular Weight:225.24
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Yield:-
Reaction Conditions:
with malonic acid in ethanol;
Steps:
A A)
A) Preparation of 3-amino-3-(2,4-dimethoxyphenyl)propionic amide A mixture of 2,4-dimethoxybenzaldehyde (21 g, 0.126 mol), malonic acid (20 g, 0.192 mol), ammonium acetate (30 g, 0.39 mol) and ethanol (40 ml) was stirred and heated on a water bath. After refluxing for 4 h the mixture was cooled to 40°C and the precipitated salt was filtered off and washed with cold ethanol (40 ml). By additional cooling on ice a further crystalline material precipitated, which was isolated and washed with cold ethanol (40 ml) and ether (40 ml). Recrystallisation from ethanol/water 60:40 gave 3-amino-3-(2,4-dimethoxyphenyl)propanoic acid (10.3 g, 38%).
References:
EP548217,1997,B1
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34841-02-6
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