![](/CAS/GIF/282524-82-7.gif)
3-AMINO-3-(4-TERT-BUTYL-PHENYL)-PROPIONIC ACID synthesis
- Product Name:3-AMINO-3-(4-TERT-BUTYL-PHENYL)-PROPIONIC ACID
- CAS Number:282524-82-7
- Molecular formula:C13H19NO2
- Molecular Weight:221.3
![Malonic acid](/CAS/GIF/141-82-2.gif)
141-82-2
737 suppliers
$5.00/25g
![4-tert-Butylbenzaldehyde](/CAS/GIF/939-97-9.gif)
939-97-9
277 suppliers
$15.00/5g
![3-AMINO-3-(4-TERT-BUTYL-PHENYL)-PROPIONIC ACID](/CAS/GIF/282524-82-7.gif)
282524-82-7
38 suppliers
$75.00/250mg
Yield:282524-82-7 79%
Reaction Conditions:
with ammonium formate in ethanol; for 7 h;Reflux;Knoevenagel Condensation;
Steps:
4.2.1 Synthesis of intermediate 12a-d
General procedure: To a solution of malonic acid (1.04g, 10mmol), ammonium formate (1.26g, 20mmol) in ethanol (50ml) was added aromatic aldehyde (10mmol). The resulting mixture was then refluxed for 7h. The reaction mixture was allowed to cool to room temperature and filtrated to yield the crude product. The crude product was further purified by recrystallization (95% ethanol) to provide the product as a white solid.
References:
Guo, Yongzhi;Zhao, Yuqian;Wang, Guan;Chen, Yi;Jiang, Yingnan;Ouyang, Liang;Liu, Bo [European Journal of Medicinal Chemistry,2018,vol. 143,p. 402 - 418]
![DL-4-Tert-butylphenylalanine](/CAS/GIF/98708-80-6.gif)
98708-80-6
43 suppliers
$27.00/100mg
![3-AMINO-3-(4-TERT-BUTYL-PHENYL)-PROPIONIC ACID](/CAS/GIF/282524-82-7.gif)
282524-82-7
38 suppliers
$75.00/250mg