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3-Amino-3-Methylpiperidine-2,6-Dione Hydrochloride synthesis

6synthesis methods
-

Yield:73839-06-2 96%

Reaction Conditions:

with hydrogenchloride in tetrahydrofuran;water at 10; for 3 h;Inert atmosphere;

References:

Hansen, Joshua D.;Correa, Matthew;Nagy, Mark A.;Alexander, Matt;Plantevin, Veronique;Grant, Virginia;Whitefield, Brandon;Huang, Dehua;Kercher, Timothy;Harris, Roy;Narla, Rama Krishna;Leisten, Jim;Tang, Yang;Moghaddam, Mehran;Ebinger, Katalin;Piccotti, Joseph;Havens, Courtney G.;Cathers, Brian;Carmichael, James;Daniel, Thomas;Vessey, Rupert;Hamann, Lawrence G.;Leftheris, Katerina;Mendy, Derek;Baculi, Frans;Lebrun, Laurie A.;Khambatta, Gody;Lopez-Girona, Antonia [Journal of Medicinal Chemistry,2020,vol. 63,# 13,p. 6648 - 6676]