ChemicalBook CAS DataBase List 3-AMINO-5-CYANO-BENZOIC ACID METHYL ESTER

3-AMINO-5-CYANO-BENZOIC ACID METHYL ESTER synthesis

5synthesis methods

Product Name:3-AMINO-5-CYANO-BENZOIC ACID METHYL ESTER
CAS Number:199536-01-1
Molecular formula:C9H8N2O2
Molecular Weight:176.17

3-CYANO-5-NITRO-BENZOIC ACID METHYL ESTER

99066-80-5
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3-AMINO-5-CYANO-BENZOIC ACID METHYL ESTER

199536-01-1
51 suppliers
inquiry

Yield: 95%

Reaction Conditions:

with hydrogen;palladium 10% on activated carbon in tetrahydrofuran;methanol at 20; for 4 h;

Steps:

75
10%Pd/C (0.9 g) was added to the solution of methyl-3-cyano-5-nitrobenoate (25 mmol) in MeOH (200 mL) and THF (100 mL). Then the solution was stirred at room temperature for 4 hours. After filtration, it was concentrated to give methyl-3-amine-5-cyanobenoate in 95% yield.

References:

Hutchison Medipharma Enterprises Limited US2009/118292, 2009, A1 Location in patent:Page/Page column 29