3-Amino-5-methyl-1-phenylpyrazole synthesis
- Product Name:3-Amino-5-methyl-1-phenylpyrazole
- CAS Number:85485-59-2
- Molecular formula:C10H11N3
- Molecular Weight:173.21
870-64-4
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100-63-0
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$10.00/1g
1131-18-6
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$10.00/25g
85485-59-2
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Yield:1131-18-6 15.62% ，85485-59-2 14.06%
Reaction Conditions:
with hydrogenchloride in methanol;water at 90; for 2 h;
Steps:
Synthesis of 3-methyl-l-phenyl-lH-pyrazol-5-amine and 5-methyl-l-phenyl-lH- pyrazol-3-amine
To a solution of (Z)-3-aminobut-2- enenitrile (4 g, 48.78 mmol) in MeOH (20 mL), HC1 (10 mL) at 0 °C and phenylhydrazine (3.1 g, 29.26 mmol) was added and heated at 90 °C for 2 h. Progress of the reaction was monitored by TLC. Upon completion the reaction mixture was evaporated under reduced pressure to obtain a residue. The crude product was purified by column chromatography to afford 3 -methyl- 1 -phenyl- lH-pyrazol-5- amine (1 g, 15.62%) and 5-methyl-l-phenyl-lH-pyrazol-3-amine (0.9 g, 14.06%)
References:
WO2016/44666,2016,A1 Location in patent:Paragraph 0431; 0432
