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3-aMino-6,8-dibroMo-2-Methylquinazolin-4(3H)-one synthesis

4synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: acetic acid; bromine / 5 h / 20 °C
2: 3 h / Reflux
3: hydrazine hydrate / ethanol / 12 h / Reflux

References:

ElZahabi, Heba S.A.;Nafie, Mohamed S.;Osman, Dina;Elghazawy, Nehal H.;Soliman, Dalia H.;EL-Helby, Abdelghany Ali H.;Arafa, Reem K. [European Journal of Medicinal Chemistry,2021,vol. 222,art. no. 113609]