ChemicalBook CAS DataBase List 3-Aminoisonicotinic acid

3-Aminoisonicotinic acid synthesis

9synthesis methods

Product Name:3-Aminoisonicotinic acid
CAS Number:7579-20-6
Molecular formula:C6H6N2O2
Molecular Weight:138.12

13959-02-9
342 suppliers
$5.00/1g

7579-20-6
270 suppliers
$10.00/1g

Yield:7579-20-6 95.2%

Reaction Conditions:

with ammonium hydroxide;copper(l) iodide at 100 - 105; for 8 h;Autoclave;Time;

Steps:

1.2; 2.2; 3.2 2. Synthesis of 3-amino-4 pyridinecarboxylic acid
50g (0.25mol) of 3-bromo-4-pyridinecarboxylic acid was added in batches to 125ml of 18% ammonia water, 1.44g (0.0075mol) of cuprous iodide was added, and the temperature was closed in an autoclave to 100-105°C and stirred for reaction 8 Hours, cooled to room temperature, adjusted the pH to 5.5-6 with 26% hydrochloric acid, filtered and dried to obtain 32.9g of 3-amino-4pyridinecarboxylic acid, yield 95.2%, HPLC purity 99.7%

References:

Suzhou Chenghe Pharmaceutical And Chemical Co., Ltd.;Chen Xiaoqiang CN111018775, 2020, A Location in patent:Sheet 0013; 0015; 0016; 0019;0020; 0023; 0024

FullText

4664-01-1 Synthesis