3-Aminopyridine-2-carboxylic acid ethyl ester synthesis
- Product Name:3-Aminopyridine-2-carboxylic acid ethyl ester
- CAS Number:27507-15-9
- Molecular formula:C8H10N2O2
- Molecular Weight:166.18
64-17-5
707 suppliers
$10.00/50g
1462-86-8
254 suppliers
$10.00/1g
27507-15-9
107 suppliers
$11.00/250mg
Yield:27507-15-9 65%
Reaction Conditions:
with hydrogenchloride at 20 - 100; for 72 h;
Steps:
Step 1 - Synthesis of ethyl 3-aminopicolinate (C-2)
A suspension of 3-aminopicolinic acid (1-18) (28 g, 200 mmoL, 1.0 eq) in EtOH (800 mL) at room temperature was bubbled with HCI (g) for 10 min. The reaction turned into a clear yellow solution. After being stirred at 100°C for 1 day, LCMS indicated that about 50% of starting material remained. The reaction mixture was cooled to rt and bubbled with HCI (g) for 10 min. The mixture was then re-heated to 100 °C. After being stirred at 100 °C for 1 day, LCMS indicated that about 50% of the starting material remained. The reaction mixture was cooled to rt and all solvents were removed under reduced pressure. The residue was resolved in EtOH (800 mL) and was bubbled with HCI (g) for 10 min. The resulting mixture was refluxed at 100°C oil bath for 1 day. LCMS indicated about 70-75 % conversion. The reaction mixture was cooled to rt and all solvents were removed under reduced pressure. The solid was dissolved in 250 mL water and the solution was quenched to pH = 8-9 with saturated aq Na2C03. A gas was generated and a white solid formed. The suspension was filtered, washed with water, and dried under vacuum at 65°C to afford 22 g of ethyl 3-aminopicolinate (1-19) in 65% yleld as a white solid. LCMS (APCI, M+ + 1 ) 167.0; 1H NMR (300 MHz, DMSO-c/6) 8 ppm 7.84 (dd, J = 4.05, 1 .60 Hz, 1 H), 7.23 - 7.30 (m, 1 H), 7.16 - 7.23 (m, 1 H), 6.65 (br. s., 2 H), 4.27 (q, J = 7.10 Hz, 2 H), 1 .30 (t, J = 7.06 Hz, 3 H).
References:
WO2016/97918,2016,A1 Location in patent:Page/Page column 55
462-08-8
470 suppliers
$14.00/25g
617-35-6
526 suppliers
$5.00/10g
27507-15-9
107 suppliers
$11.00/250mg
119830-47-6
48 suppliers
$45.00/10mg
119830-48-7
0 suppliers
inquiry