3-(AMINOSULFONYL)PROPANOIC ACID synthesis

Yield:-

Reaction Conditions:

with potassium hydroxide in water for 1 h;Reflux;

Steps:

An aqueous solution of potassium hydroxide (6.71 g, 0.120 mol) in 50 mL of water was added to a solution of compound 3 (10 g, 0.066 mol) in 50 mL of water. The reaction mass was refluxed for 1 hour, cooled to room temperature, and 10% HCl was added thereto to pH 2-3 and removed under vacuum to dryness. Acetone (150 mL) was added to the resulting residue and stirred for 30 min, and the residue was filtered off and washed with acetone (100 mL). The filtrate was separated and removed under vacuum, and obtained colorless crystalline product 4 was dried in air to a constant weight.

References:

OBSCHESTVO S OGRANICHENNOI OTVETSTVENNOSTIYU "PHARMENTERPRISES";NEBOLSIN, Vladimir Evgenievich;KROMOVA, Tatyana Alexandrovna US2017/183318, 2017, A1 Location in patent:Paragraph 0201; 0204

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