3-(Azetidin-3-yloxy)-benzonitrile synthesis
- Product Name:3-(Azetidin-3-yloxy)-benzonitrile
- CAS Number:954223-73-5
- Molecular formula:C10H10N2O
- Molecular Weight:174.2
1350362-24-1
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Yield:954223-73-5 262.3 mg
Reaction Conditions:
with trifluoroacetic acid in dichloromethane at 20; for 2 h;
Steps:
1.1.4.2 1 .4.2 Synthesis of 3-(azetidin-3-yloxy)benzonitrile a1 -45.
Trifluoroacetic acid (10 ml) is added to a solution of tert-butyl 3-(3- cyanophenoxy)azetidine-1-carboxylate a1 -43 (260 mg, 0.95 mmol, 1 eq) in dichloromethane (10 ml). The reaction mixture is stirred for 2 hours at room temperature, then concentrated to dryness to afford 262.3 mg of crude 3-(azetidin-3- yloxy)benzonitrile a1 -45 as an oil. This oil is used in the next step without any further purification.Yield: 100%. LC-MS (MH+): 175.
References:
WO2013/53725,2013,A1 Location in patent:Page/Page column 40-41
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