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3-(benzhydrylamino)-3-methylbutan-2-one synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: potassium chloride; bromine / water / 3 h / 40 - 60 °C / irradiation with a 250W incandescent lamp; then irradiation with a 100W incandescent lamp
2: triethylamine / methanol / 24 h / 70 °C

References:

DAIICHI PHARMACEUTICAL CO., LTD. EP1591443, 2005, A1