3-BENZOYL-2-CHLOROPYRIDINE synthesis

11synthesis methods

Product Name:3-BENZOYL-2-CHLOROPYRIDINE
CAS Number:80099-81-6
Molecular formula:C12H8ClNO
Molecular Weight:217.65

49609-84-9
232 suppliers
$20.00/5g

100-58-3
183 suppliers
$18.00/10ml

80099-81-6
22 suppliers
inquiry

Yield:80099-81-6 96 %

Reaction Conditions:

with copper(II) catalyst immobilized on poly[3-(carboxypropy)thiophene-2,5-diyl] wrapped in carbon nanotubes in tetrahydrofuran at 0;Inert atmosphere;Kumada Cross-Coupling;Reagent/catalyst;

Steps:

2.4 Typical Procedure for the Coupling Reaction of Grignard Reagent with Acid Chloride Using Cu(at)PCPT(at)CNT

General procedure: To a 25mL round-bottom flask equipped with a magnetic stirbar, phenylmagnesium bromide (1.0M in THF, 2.0mmol), Cu(at)PCPT(at)CNT (40 mg) and dried THF (2.0 mL) were placed in Argon atmosphere. Next, benzoyl chloride (3.0 mmol) was added dropwise under argon atmosphere in an ice-bath. After being stirred at 0°C for 30min, the reactionmixture was filtered and washed with water. The combinedfltrate was quenched with saturated ammonium chloride solutionand extracted with diethyl ether (3 × 10mL). The organiclayers were washed with brine, and dried over anhydrousNa2SO4.The volatile components were evaporated underreduced pressure. Purification was carried out by flash column chromatography on silica gel using 2% ethyl acetate/98%hexanes as an eluent.

References:

Soo-Jung, Kwak;Seong-Ryu, Joo;Ji-Hye, Kang;Shin, Ueon Sang;Seung-Hoi, Kim [Catalysis Letters,2022]