3-(BENZYLMETHYLAMINO)-1-PROPANOL synthesis
- Product Name:3-(BENZYLMETHYLAMINO)-1-PROPANOL
- CAS Number:5814-42-6
- Molecular formula:C11H17NO
- Molecular Weight:179.26
Yield:-
Reaction Conditions:
Stage #1: benzyl-methyl-amine;1-bromo-3-propanol in methanol; for 16.3333 h;Heating / reflux;
Stage #2: with sodium hydroxide in methanol;water at 20;
Steps:
6 Example 6; Preparation of [4- (N-BENZYL-N-METHYLAMINO)] butyraldehyde [DIETHYLACETAL] of formula-I where [R'=] Me, R2 = [BENZYL, R3] = Et using benzene as solvent:; Preparation of [3- (N-BENZYL-N-METHYLAMINO) PROPANOL] :
To a solution of 278gr of 3- bromopropanol in [400ML] of methanol was added drop-wise a solution of 240gr of N- [BENZYLMETHYLAMINE] in 100ml of methanol. After 20min, the solution was heated under reflux and mainted for [16HR.] The reaction mixture was cooled to room temperature and poured into water [(1000ML)] containing [LOOGR] of [NAOH.] Product was extracted into benzene (2 x [500ML)] and distilled off benzene to get 200gr of crude compound. This was distilled under high vaccum to get [150GR] of distilled [3-(N-BENZYL-N-] methylamino) propanol.
References:
WO2003/101931,2003,A2 Location in patent:Page 16
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