ChemicalBook CAS DataBase List 3-(Benzyloxy)-4-Methoxyphenylacetic Acid

3-(Benzyloxy)-4-Methoxyphenylacetic Acid synthesis

10synthesis methods

Product Name:3-(Benzyloxy)-4-Methoxyphenylacetic Acid
CAS Number:5487-33-2
Molecular formula:C16H16O4
Molecular Weight:272.3

1131-94-8
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100-39-0
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3-(Benzyloxy)-4-Methoxyphenylacetic Acid

5487-33-2
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$172.00/100mg

Yield:5487-33-2 91.9%

Reaction Conditions:

with potassium iodide;potassium hydroxide in methanol at 20; for 8 h;Reflux;Reagent/catalyst;Solvent;Temperature;

Steps:

1.4; 3.4 (4) Preparation of Compound 6

To a 1 L three-necked flask were added 45 g of compound 5, 1.6 g of potassium iodide, 38 g of potassium hydroxide and 350 g of methanol, and 64 g of benzyl bromide was added dropwise at room temperature. After the dropwise addition, the mixture was heated to reflux for 8 hours, and the starting material was completely reacted. After cooling to room temperature, 150 g of water was added, and pH was adjusted to about 1 with 10% dilute hydrochloric acid to precipitate a large amount of solid. Filtration, filter cake was stirred twice with water, dried at 60 ° C to give a yellow solid 61.8 g, that is, compound 6, the yield was 91.9%.

References:

CN109942593,2019,A Location in patent:Paragraph 0053; 0072

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100-44-7 Synthesis