ChemicalBook CAS DataBase List 3-(Benzyloxy)-5-broMo-2-chloropyridine

3-(Benzyloxy)-5-broMo-2-chloropyridine synthesis

7synthesis methods

Product Name:3-(Benzyloxy)-5-broMo-2-chloropyridine
CAS Number:891785-18-5
Molecular formula:C12H9BrClNO
Molecular Weight:298.56

286946-77-8 Synthesis

286946-77-8
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$13.00/100mg

100-39-0
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$10.00/10g

891785-18-5
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$36.00/100mg

Yield:891785-18-5 98%

Reaction Conditions:

with caesium carbonate in N,N-dimethyl-formamide at 0 - 20; for 12 h;

Steps:

1.1 Step 1) Synthesis of A6

A mixture of 5-bromo-2-chloropyridine-3-ol (A5, 5.0 g, 2.40 mmol) and cesium carbonate (Cs₂CO₃, 12.0 g, 36.820 mmol) in dimethylformamide (DMF, 50 mL) was stirred at 0° C. To this stirred mixture was added benzyl bromide (3.40 ml, 28.57 mmol), slowly. The resulting solution was stirred at room temperature for 12 h. The mixture was diluted in ethyl acetate (EA). The organic layer was washed with distilled water, dried over Na₂SO₄, concentrated under reduced pressure to afford compound A6 (7.02 g) in 98.0% yield. ESI MS(m/e)=340 [M+CH₃CN+H]⁺.

References:

US2022/298113,2022,A1 Location in patent:Paragraph 0047-0048