3-BENZYLOXYCARBONYLAMINO-3-P-TOLYL-PROPIONIC ACID synthesis

Yield:406726-22-5 78%

Steps:

200 6-(3-Benzyloxycarbonylamino-3-p-tolyl-propionylamino)-hexanoic acid methyl ester (3/48)

Example 200 6-(3-Benzyloxycarbonylamino-3-p-tolyl-propionylamino)-hexanoic acid methyl ester (3/48) Using an analogous method (J4A), the title compound was obtained from 3-benzyloxycarbonylamino-3-p-tolyl-propionic acid (1/48), yield 78%. ¹H NMR (CDCl₃, HMDSO), δ: 0.94-1.74(m, 6H); 2.25(t, J=7.0 Hz, 2H); 2.32(s, 3H); 2.63(dd, J=6.0 and 4.0 Hz, 2H); 3.12(q, J=6.0 Hz, 2H); 3.65(s, 3H); 4.87-5.16(m, 1H); 5.07(s, 2H); 5.49(br s, 1H);6.27-6.52(m, 1H); 7.14(s, 4H); 7.34(s, 5H).

References:

US2004/92598,2004,A1