![](/CAS/GIF/17965-71-8.gif)
3-Bromo-1,5-naphthyridine synthesis
- Product Name:3-Bromo-1,5-naphthyridine
- CAS Number:17965-71-8
- Molecular formula:C8H5BrN2
- Molecular Weight:209.04
![1,5-NAPHTHYRIDINE](/CAS/GIF/254-79-5.gif)
254-79-5
189 suppliers
$8.00/250mg
![3-Bromo-1,5-naphthyridine](/CAS/GIF/17965-71-8.gif)
17965-71-8
130 suppliers
$27.00/100mg
Yield:17965-71-8 55%
Reaction Conditions:
with bromine;sodium acetate in acetic acid at 85; for 5 h;
Steps:
3-Bromo-1,5-naphthyridine (5)
3-Bromo-1,5-naphthyridine (5) To a stirring solutionof compound 4 (2.7 g, 20.76 mmol) and NaOAc(3.41 g,41.52 mmol) in 10 mL glacial AcOH at 85°C was added a solution of Br2 (1 M) in AcOH (35 mL) for 5 h,then cooled to room temperature and concentrated in vacuum to remove AcOH.Purification by chromatography (PE/EA = 2:1) provided compound 5 (2.36 g, 55%) as a whitesolid. MP: 107~108°C (Ref.2 108~109°C).1H NMR (400 MHz,CDCl3): δ 8.96 (d, J = 2.1 Hz, 2H), 8.56 (s, 1H), 8.36 (d, J = 8.5 Hz, 1H), 7.69-7.56 (m, 1H).
References:
Wu, Jing-Fang;Liu, Ming-Ming;Huang, Shao-Xu;Wang, Yang [Bioorganic and Medicinal Chemistry Letters,2015,vol. 25,# 16,art. no. 22772,p. 3251 - 3255] Location in patent:supporting information
![1,5-naphthyridine N-(1)-oxide](/CAS/20150408/GIF/27305-48-2.gif)
27305-48-2
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inquiry
![2-Bromo-1,5-naphthyridine](/CAS/GIF/51532-07-1.gif)
51532-07-1
47 suppliers
inquiry
![3-Bromo-1,5-naphthyridine](/CAS/GIF/17965-71-8.gif)
17965-71-8
130 suppliers
$27.00/100mg
![1,5-NAPHTHYRIDINE](/CAS/GIF/254-79-5.gif)
254-79-5
189 suppliers
$8.00/250mg
![3,7-Dibromo-1,5-naphthyridine](/CAS/GIF/17965-72-9.gif)
17965-72-9
62 suppliers
$15.00/250mg
![3-Bromo-1,5-naphthyridine](/CAS/GIF/17965-71-8.gif)
17965-71-8
130 suppliers
$27.00/100mg
![3-Amino-5-bromopyridine](/CAS/20180808/GIF/13535-01-8.gif)
13535-01-8
382 suppliers
$3.00/1g
![Glycerol](/CAS/GIF/56-81-5.gif)
56-81-5
1636 suppliers
$5.00/25g
![3-Bromo-1,5-naphthyridine](/CAS/GIF/17965-71-8.gif)
17965-71-8
130 suppliers
$27.00/100mg
![3-Amino-5-bromopyridine](/CAS/20180808/GIF/13535-01-8.gif)
13535-01-8
382 suppliers
$3.00/1g
![3-Bromo-1,5-naphthyridine](/CAS/GIF/17965-71-8.gif)
17965-71-8
130 suppliers
$27.00/100mg