3-Bromo-1-propanesulfonic acid synthesis

Yield:73384-82-4 15 g

Reaction Conditions:

Stage #1: 1,3-dibromo-propanewith sodium sulfite in ethanol at 80; for 10 h;
Stage #2: with hydrogenchloride in water at 20; pH=1 - 3;

Steps:

2.1 Example 2

1 Add 10.4 g of sodium sulfite (1.0 eq) to the reaction flask. 1,3-dibromopropane 50g (3.0eq), 200 ml of ethanol, After the addition, the temperature was raised to 80 degrees for 10 hours. Cool down to 10 degrees, filter, Obtained crude sodium 1-bromo-3-propane sulfonate, (Unreacted 1,3-dibromopropane is recovered in the filtrate). 2 Add the sodium 1-bromo-3-propane sulfonate obtained in the previous step to the reaction bottle. Add 60 ml of water, Adjust the pH to 1-3 by adding hydrochloric acid below 20 degrees. Concentrate under reduced pressure to remove most of the water. Add 35 ml of ethanol, Cool down to 10 degrees, filter, The filtrate was concentrated to dryness to give 15 g of 1-bromo-3-propanesulfonic acid.

References:

CN108218826,2018,A Location in patent:Paragraph 0027; 0035; 0036; 0037