3-bromo-2-chloro-6-fluorobenzonitrile synthesis
- Product Name:3-bromo-2-chloro-6-fluorobenzonitrile
- CAS Number:1421620-33-8
- Molecular formula:C7H2BrClFN
- Molecular Weight:234.45
668-45-1
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1421620-33-8
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Yield:1421620-33-8 47%
Reaction Conditions:
with N-Bromosuccinimide;trifluorormethanesulfonic acid at 0 - 20;Inert atmosphere;
Steps:
xviii.a a) 3-Bromo-2-chloro-6-fluorobenzonitrile I43
a) 3-Bromo-2-chloro-6-fluorobenzonitrile I43 To a solution of 2-chloro-6-fluorobenzonitrile (1.0 g, 6.4 mmol) in trifluoromethanesulfonic acid (10 ml.) at 0 °C under N2 was added NBS (1.1 g, 6.4 mmol) and the mixture was stirred at RT overnight. The mixture was poured onto ice and extracted with EtOAc (30 ml. x 2). The combined organic extracts were dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by column chromatography (Pet. ether/EtOAc = 200/1 to 100/1) to give [85] the title compound (705 mg, 47%) as a white solid, which was used directly in the next step.
References:
WO2019/243491,2019,A1 Location in patent:Page/Page column 84-85
1421620-32-7
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1421620-33-8
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