3-bromo-2-(chloromethyl)thiophene synthesis
- Product Name:3-bromo-2-(chloromethyl)thiophene
- CAS Number:7353-88-0
- Molecular formula:C5H4BrClS
- Molecular Weight:211.51
70260-17-2
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Yield:7353-88-0 84%
Reaction Conditions:
with thionyl chloride in dichloromethane; for 4 h;Reflux;
Steps:
1.1.2
(3-Bromo-thiophen-2- yl)-methanol (505 mg, 2.62 mmol) was dissolved in dichloromethane (20 mL) and thionyl chloride (357 μ, 4.89 mmol) was added. The mixture was heated at reflux for 4 firs, then evaporated. The crude product was purified by column chromatography on silica, eluting with dichloromethane. The title compound (466 mg, 2.20 mmol, 84%) was obtained as a pale yellow oil.
References:
WO2011/156640,2011,A2 Location in patent:Page/Page column 134
930-96-1
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