ChemicalBook CAS DataBase List 3-Bromo-2-chlorophenol

3-Bromo-2-chlorophenol synthesis

7synthesis methods

Product Name:3-Bromo-2-chlorophenol
CAS Number:863870-87-5
Molecular formula:C6H4BrClO
Molecular Weight:207.45

326.4 g (2.04 moles) of bromine is added dropwise in 6 hours with vigorous stirring, within a temperature range of between 20° and 45° C., to a mixture of 257.2 g (2 moles) of 2-chlorophenol, 1.0 g of zinc chloride and 1.0 g of diphenyl sulfide. After adding 70 ml of bromine, the temperature rises to 35° C. To avoid crystallization, the reaction mixture is afterwardheated to 40° C., Afterward, 20 ml of bromine is added dropwise. The remaining bromine is finally added at 45° C. After the addition of bromine is complete, stirring is maintained for 30 minutes at 50° C., and subsequently, the reaction product is freed at 60° C. under reduced pressure from dissolved hydrogen bromide to leave 414.5 g (99.8% of theory) of chlorobromophenol(3-Bromo-2-chlorophenol).

95-57-8 Synthesis

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863870-87-5
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Yield:-

Steps:

5 EXAMPLE 5
EXAMPLE 5 257 g (2 moles) of 2-chlorophenol is brominated, in the manner described in Example 1, with the use of a variety of catalyst mixtures. Chlorobromophenol is thus obtained in yields of 99.5 to 99.8% of theory.

References:

Ciba-Geigy Corporation US4210766, 1980, A

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