3-Bromo-2-fluorobenzamide synthesis
- Product Name:3-Bromo-2-fluorobenzamide
- CAS Number:871353-25-2
- Molecular formula:C7H5BrFNO
- Molecular Weight:218.02
161957-56-8
273 suppliers
$6.00/1g
871353-25-2
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$29.00/250mg
Yield:871353-25-2 98%
Reaction Conditions:
Stage #1: 3-bromo-2-fluorobenzoic acidwith thionyl chloride in dichloromethane; for 6 h;Reflux;
Stage #2: with ammonia in water;ethyl acetate;
Steps:
17 3-Bromo-2-fluorobenzamide
Example 17 3-Bromo-2-fluorobenzamide To a stirred solution of 3-bromo-2-fluorobenzoic acid (24.3 g, 111 mmol) in CH2Cl2 (100 mL) was added SOCl2 (12.2 mL, 166 mmol). The mixture was stirred under reflux for 6 h until the solution is colorless. CH2Cl2 was removed under vacuum. Then the residue was dissolved in ethyl acetate (200 mL) and then added dropwise to NH3H2O (80 mL). The organic layer was washed with H2O (50 mL*2), brine and dried over Na2SO4, filtered and concentrated to give 23.8 g of the title compound as a white solid (98% yield).
References:
US2009/203677,2009,A1 Location in patent:Page/Page column 50
374554-41-3
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$35.00/1g
871353-25-2
45 suppliers
$29.00/250mg
1072-85-1
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$5.00/10g
871353-25-2
45 suppliers
$29.00/250mg