3-BROMO-4-(4-CHLORO-PHENYL)-4-OXO-BUTYRIC ACID synthesis

Yield:35158-39-5 84%

Reaction Conditions:

with bromine in dichloromethane;

Steps:

1C General procedure for preparation of bromoketoacids (compounds 4.4.01-10):

The aryl ketoacid (either synthesized in-house or purchased from a commercial source) was dissolved in dichloromethane (0.2 M) and cooled to 0° C. The Br₂ (1.1 equiv) was added dropwise, then the reaction was warmed to room temperature and stirred until reaction was complete as judged by TLC analysis. For some more slowly-reacting derivatives, the reaction mixture was heated to reflux at 40° C. The reaction mixture was concentrated in vacuo to yield the brominated ketoacid which could be further purified if necessary by recrystallization in dichloromethane.

References:

US2017/258805,2017,A1 Location in patent:Paragraph 0381; 0382