3-Bromo-4-methylbenzenesulphonamide synthesis
- Product Name:3-Bromo-4-methylbenzenesulphonamide
- CAS Number:210824-69-4
- Molecular formula:C7H8BrNO2S
- Molecular Weight:250.11
70-55-3
567 suppliers
$6.00/100g
210824-69-4
35 suppliers
$72.50/1g
Yield:-
Reaction Conditions:
with bromine;iron at 20; for 1 h;
Steps:
106.1
To a mixture of p-toluenesulfonamide (2 g, 1.16 mmol) and iron (0.41 g, 7.36 mmol) was slowly added bromine (6 mL, 116 mmol). The resulting reddish brown solution was stirred at RT for 1 h. The reaction was carefully poured into ice-cold 1 M Na2S2O3 aqueous solution and extracted with CH2Cl2 (2×). The organic extracts were combined and washed with brine, dried (MgSO4), filtered, and concentrated in vacuo. CombiFlash purification (1% to 10% MeOH/CH2Cl2) afforded the title compound as a white solid. 1H NMR (DMSO-d6, 400 MHz): 7.98 (s, 1H), 7.71 (d, J=8 Hz, 1H), 7.55 (d, J=8 Hz, 1H), 7.54 (br s, 2H), 2.41 (s, 3H).
References:
Amgen Inc. US2006/199817, 2006, A1 Location in patent:Page/Page column 53
7745-91-7
316 suppliers
$6.00/5g
210824-69-4
35 suppliers
$72.50/1g