3-Bromo-5-(3-methylphenoxy)pyridine synthesis

Yield:28231-75-6 17%

Reaction Conditions:

with pyridine;copper (II) acetate in dichloromethane at 20;

Steps:

6 Synthesis of 4-(5-(m-Tolyloxy)pyridin-3-yl)2-hydroxybenzoic acid (A6)

3-Hydroxy-5-bromopyridine (1.54 g, 8.8 mmol) and 3-methylphenylboronic acid (2.4 g, 17.7 mmol) were dissolved in dichloromethane, pyridine (2.1 mL, 26.4 mmol) was added, copper acetate (0.4 g, 2.2 mmol), stirred at room temperature overnight, extracted with dichloromethane, dried over anhydrous sodium sulfate, ethyl acetate: petroleum ether (volume ratio 1:5) column chromatography to obtain a white solid 3-bromo-5-m-tolyloxy pyridine 0.4 g, yield 17%.

References:

CN114805192,2022,A Location in patent:Paragraph 0078-0080