3-bromo-5,5-dimethyl-4H-1,2-oxazole synthesis
- Product Name:3-bromo-5,5-dimethyl-4H-1,2-oxazole
- CAS Number:882697-80-5
- Molecular formula:C5H8BrNO
- Molecular Weight:178.0271
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Yield:882697-80-5 95 g
Reaction Conditions:
with anhydrous sodium carbonate in 1,2-dichloro-ethane at 40 - 45;
Steps:
1
After the reaction, separate layers, transfer the lower dichloroethane layer into another 500mL four-necked flask, first add 107.4g sodium carbonate (1.01mol, 1.5eq), then control the temperature at 4045 to pass 56.7g Isobutylene (1.01mol, 1.5eq) undergoes cyclization reaction, and after suction filtration,The mother liquor was evaporated to dryness to obtain 95.0 g of 3-bromo-5,5-dimethyl-4,5-dihydroisoxazole.The purity is 96%, and the yield is 79.0%.
References:
CN113336716,2021,A Location in patent:Paragraph 0009; 0025-0029
74213-24-4
190 suppliers
$7.00/250mg
882697-80-5
9 suppliers
inquiry