ChemicalBook CAS DataBase List 3-Bromo-5-chlorosalicylaldehyde

3-Bromo-5-chlorosalicylaldehyde synthesis

2synthesis methods

Product Name:3-Bromo-5-chlorosalicylaldehyde
CAS Number:19652-32-5
Molecular formula:C7H4BrClO2
Molecular Weight:235.46

635-93-8
348 suppliers
$6.00/5g

19652-32-5
207 suppliers
$10.00/5g

Yield: 99%

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide at 20; for 72 h;

Steps:

15
Description 15 (D15) 3-bromo-5-chloro-2-hvdroxybenzaldehydeA solution of 5-chloro-2-hydroxybenzaldehyde (5.00 g, 31.93 mmol) and N- bromosuccinamide (5.68 g, 31.93 mmol) in dry DMF (64 ml) was stirred at room temperature under an atmosphere of argon for 72 hours (over the weekend). The reaction was monitored by LC-MS. The reaction mixture was diluted with EtOAc and washed with water (x3). Brine was added to encourage separation. The organics were dried over magnesium sulfate, filtered and concentrated under reduced pressure to give an orange solid, 3-bromo-5-chloro-2-hydroxybenzaldehyde (7.42 g, 99%) Rt = 2.92min, [M-H]^" 233, 235

References:

GLAXO GROUP LIMITED WO2008/98978, 2008, A2 Location in patent:Page/Page column 37-38

67-66-3 Synthesis

67-66-3
6 suppliers
$33.60/500ml

695-96-5 Synthesis

695-96-5
258 suppliers
$7.00/5g

19652-32-5
207 suppliers
$10.00/5g

References

3-Bromo-5-chlorosalicylaldehyde Related Search:

Salicylaldehyde 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 3-bromo-5-chloro-2-methoxybenzaldehyde RARECHEM AL BF 0302