3-broMo-5-Methanesulfonylaniline synthesis
- Product Name:3-broMo-5-Methanesulfonylaniline
- CAS Number:62606-00-2
- Molecular formula:C7H8BrNO2S
- Molecular Weight:250.11
31948-87-5
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20277-69-4
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62606-00-2
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62606-01-3
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Yield:62606-00-2 42%
Reaction Conditions:
with copper(l) iodide;L-proline;sodium hydroxide in dimethyl sulfoxide at 60;
Steps:
S3.A General Procedure S (Sulfone Coupling).
General procedure: The corresponding aryl iodide or bromide (1 eq) was combined with sodium methanesulfinate (1.2 eq), Cul (0.10 eq), L- proline (0.20 eq) and NaOH (0.2 eq). The reaction vessel was purged with Ar, sufficient DMSO to produce a 0.5 M concentration was added, and the mixture was heated at 57- 85 °C for 16-20 h. Upon cooling, the mixture was diluted with water and extracted with CH2CI2. The organic phase was dried and concentrated. The crude material was taken forward without purification.
References:
WO2021/21951,2021,A1 Location in patent:Paragraph 00520; 001244-001245
62606-15-9
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62606-00-2
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