3-BroMo-6-chloropyridin-2-ol synthesis

Yield:-

Reaction Conditions:

with N-Bromosuccinimide in chloroform; for 2 h;Heating / reflux;

Steps:

2A 3-Bromo-6-chloro-pyridin-2-ol

A mixture of 2-chloro-6-hydroxypyridine (2 g, 15.4 mmol) and NBS (2.8 g, 16 mmol) in 20 mL of chloroform was refluxed for 2 hours. The solvent was removed in vacuo and the residue purified by flash column chromatography. 2.1 g of a mixture of mono-bromination products was obtained. This material was used directly in the next step.

References:

US2005/65144,2005,A1 Location in patent:Page/Page column 47-48