3-bromo-6-ethoxy-2-Pyridinecarbonitrile synthesis
- Product Name:3-bromo-6-ethoxy-2-Pyridinecarbonitrile
- CAS Number:1353777-41-9
- Molecular formula:C8H7BrN2O
- Molecular Weight:227.06
Yield:-
Reaction Conditions:
with triethylamine in acetonitrile at 100; for 24 h;
Steps:
XXXVII.1.b
b)1.00 g (4.59 mmol) 5-bromo-2-ethoxy-pyridine-1-oxide, 2.46 mL (18.3 mmol) trimethylsilyl cyanide and 1.92 mL (13.8 mmol) TEA in 10 mL ACN are stirred together at 100° C. for 24 h. Then the volatile components are removed in vacuo and the residue is dissolved in DCM, washed with aq. NaHCO3 solution, dried with MgSO4 and filtered through a plug of silica gel. Then the solvent is removed in vacuo.C8H7BrN2O (M=227.1 g/mol), ESI-MS: 227 [M+H]+Rf (TLC): 0.85 (silica gel, PE /EtOAc 7 /3)
References:
US2012/157425,2012,A1 Location in patent:Page/Page column 66
55849-30-4
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