3-BroMo-N-Methyl-benzeneethanaMine synthesis

4synthesis methods

Product Name:3-BroMo-N-Methyl-benzeneethanaMine
CAS Number:785032-26-0
Molecular formula:C9H12BrN
Molecular Weight:214.1

50-00-0 Synthesis

50-00-0
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58971-11-2
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785032-26-0
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$328.70/1gm:

Yield:785032-26-0 75%

Reaction Conditions:

with sodium tris(acetoxy)borohydride in 1,2-dichloro-ethane at 90; for 0.0833333 h;Microwave irradiation;

Steps:

A [2-(3-Bromo-phenyl)-ethyl]-methyl-amine

2-(3-Bromo-phenyl)-ethylamine (0.5 mmol) and formaldehyde (0.42 mmol) were mixed in 3 ml of 1,2-dichloroethane in a process vial, which was sealed with a septum. Sodium triacetoxyborohydride (0.84 mmol) was added under argon atmosphere. The suspension was subjected to microwave irradiating conditions (CEM Discover equipped with a CEM Explorer automated reaction handling module). The reaction mixture was heated for 5 min at 90°C and then cooled. The crude was evaporated to dryness and then suspended in aqueous NaHCO₃. The product was extracted with CH₂Cl₂ and washed with aqueous NaHCO₃. The CH₂Cl₂ extract was dried with anhydrous Na₂SO₄, filtered and evaporated to dryness to give the crude product [2-(3-bromo-phenyl)-ethyl]-methyl-amine. The crude was purified by flash column chromatography (CH₂Cl₂-MeOH as eluents) by using a CombiFlash Companion system to yield the title compound (75%) as colourless oil.