ChemicalBook CAS DataBase List 3-Bromobenzylamine

3-Bromobenzylamine synthesis

6synthesis methods

Product Name:3-Bromobenzylamine
CAS Number:10269-01-9
Molecular formula:C7H8BrN
Molecular Weight:186.05

3132-99-8 Synthesis

3132-99-8
482 suppliers
$5.00/10g

10269-01-9
194 suppliers
$8.00/1g

Yield:10269-01-9 98.2%

Reaction Conditions:

with ammonium hydroxide;hydrogen in methanol;water at 30; under 1520.1 Torr; for 4 h;Reagent/catalyst;

Steps:

1-8 Example 3
_{In a 500ml hydrogenation kettle, add 200ml methanol, 49.5g (0.268mol) 3-bromobenzaldehyde,5.0g Raney nickel catalyst (containing water), then add 27.34g ammonia water (25%, 0.402mol),Carry out hydrogen replacement reaction: temperature 30°C,Hydrogen pressure 2atm, reaction time 4h.After the reaction, the solution was filtered and concentrated to obtain the first reaction product m-bromobenzylamine 48.6g,The yield was 98.2% and the gas phase purity was 94.9%.}

References:

Nanjing Jieyun Pharmaceutical Technology Co., Ltd.;Zhang Li;Fang Jing;Shu Kai;Zhou He;Song Xingchang;Yu Zenghui;Wu Xiaodong;Liu Haomin CN110938028, 2020, A Location in patent:Paragraph 0044; 0050-0051; 0054-0055; 0058-0059; 0062-0063

FullText